diff --git a/python/setup.py.in b/python/setup.py.in
index 8d00e078..3b20ef14 100644
--- a/python/setup.py.in
+++ b/python/setup.py.in
@@ -40,7 +40,7 @@ setup(name="opendht",
           "opendht",
           ["@CURRENT_SOURCE_DIR@/opendht.pyx"],
           language="c++",
-          extra_compile_args=["-std=c++17"],
+          extra_compile_args=["-std=c++17", "-DMSGPACK_NO_BOOST", "-DMSGPACK_DISABLE_LEGACY_NIL", "-DMSGPACK_DISABLE_LEGACY_CONVERT", "-DOPENDHT_INDEXATION", "-Dopendht_EXPORTS"],
           extra_link_args=["-std=c++17"],
           libraries=["opendht"],
           include_dirs = ['@PROJECT_SOURCE_DIR@/include'@OPENDHT_PYTHON_INCLUDE_DIRS@],